清末民初,佛山武学宗师黄飞鸿因(yīn )噩(è )梦(mèng )预(yù )感(gǎn )女(nǚ )记(jì )者(zhě )莫(mò )十(shí )三(sān )遇(yù )险,携弟子前往古云村寻人。村中蜈蚣教借蛊术胁迫村民献祭孩童,莫十三探查真相时被擒,身中噬魂蛊。黄飞鸿闯祭坛救人,因不忍伤及被蛊惑的村(cūn )民(mín )反(fǎn )中(zhōng )蛊(gǔ )毒(dú ),幸(xìng )得卧底蜈蚣教的鬼脚七暗中相助。众人合力破除水源蛊毒,救治村民,鬼脚七伤愈拜师。巫师自焚后,线索指向广州(zhōu )东(dōng )瀛(yíng )会(huì )馆(guǎn )。黄(huáng )飞(fēi )鸿(hóng )潜(qián )入(rù )会(huì )馆救出被掳孩童,对决主事服部一郎,得知幕后黑手为西洋吸血鬼麦克罗。麦克罗散播疫毒祸乱羊城,以莫十三性命相要挟。黄飞鸿于绝境中融合腿(tuǐ )法(fǎ ),悟(wù )出(chū )佛(fó )山(shān )无(wú )影脚,击杀麦克罗。蛊毒尽解,百姓恢复神智,广州重归太平,宝芝林重回烟火日常。